Department of Biochemistry and Molecular Biology

Dr. Khokon Kumar Dutta

Blood Group:

Assistant Professor

Phone: +8801731231551

E-mail: kkdutta@bsmrstu.edu.bd

Address:

Current Research working Topic


  • Investigation of thioredoxin-binding protein-2 (TBP-2) level inside the pancreatic mitochondria of diabetic and non-diabetic rats.

Short Biography


  • Dr. Khokon Kumar Dutta, S/O. Late Balai Chandra Dutta and Late Sudha Rani Dutta was born in Jhenaidaha, Bangladesh on January 1st, 1975. He was born in a Hindu family. He is baptized and accepted the Christianity in 2015. Dr. Khokon Kumar Dutta was awarded PhD degree from the School of Medicine, Kyoto University, Japan in 2007. In both B.Sc. and M.Sc., he studied Biochemistry and Molecular Biology in the University of Dhaka, Bangladesh. In higher secondary school level he qualified for studying in Notre Dame College, Dhaka College and Dhaka Residential Model College. He started his higher secondary school in Notre Dame College and subsequently moved to Dhaka College. He also got the opportunity to study the Bachelor of Medicine and Bachelor of Surgery (MBBS), but choose to study Biochemistry and Molecular Biology in Dhaka University. He is working as assistant professor at the Department of Biochemistry and Molecular Biology in Bangabandhu Sheikh Mujibur Rahman Science and Technology University, Gopalgonj from 22nd April 2018. Currently he is also serving as the chairman of the department.
    Dr. Khokon Kumar Dutta has some disease related research experiences. He started his institutional research as a M.Sc. thesis student in immunology in the International Centre for Diarrhoeal Disease Research, Bangladesh (ICDDR B) where he subsequently worked as a research employee.He did some postdoctoral research as Research Associate in the School of Optometry, Indiana University, USA. He also worked at the Institute for Virus Research, Kyoto University, Japan and at the National Health Research Institute, Taiwan (Republic of China).He played key roles in some research works of good significance-
    -> Both vibrio cholerae and Enterotoxic Escherichia coli infections in humans cause inflammatory responses which were largely known as non-inflammatory diseases.
    -> Discovery of the presence of CpG island in the promoter region of thiredoxin-binding protein-2, TBP-2 (also known as thioredoxin-interacting protein, TXNIP). Discovery of the mechanism of TBP-2 transcription from the chromosomal sequences which is regulated by CpG island methylation and demethylation. Abnormal expression of TBP-2 (TXNIP) is now well known as a critical contributor in different human diseases like aging, type 1 and type 2 diabetes mellitus, cardiovascular diseases, cancers, brain diseases, eye diseases, kidney diseases and others.
    -> Discovery of the presence of TBP-2 (TXNIP) inside the mitochondria of rat renal proximal tubular cells.
    -> First experimental validation of the presence of TBP-2 (TXNIP) in both cytoplasm and nucleus by using direct assay method.
    -> TBP-2 (TXNIP) physically binds with the mitochondrial thioredoxin (Trx-2)
    -> Discovery that states the half-life of TBP-2 (TXNIP) protein can be shortened by post translational mechanisms and regulators.
    -> Reduced presence or absence of TBP-2 (TXNIP) is needed for the growth and proliferation of cancer cells and for the regenerative growth of non-cancer cells.
    -> Mutations in the genomes follow a non-random pattern which simply indicates the existence of genomic locations or sites where the mutations rate is higher than other places of the genomes.
    -> MicroRNAs expression is cell-type dependent which was thought to be organ specific.
    -> Discovery of the presence of mature microRNA-34a inside the nucleus. At that time it was known that mature microRNAs are produced and function in the cytoplasm only.
    -> Some cancer types show high presence of microRNA-34a. There also exist some cancer types where microRNA-34a is almost absent.
    -> Discovery of the presence of microRNA-34c in the rat testis. Now microRNA-34c is well established as the father's microRNA. MicroRNA-34c enters the new embryo via male sperm. Success of pregnancy is largely dependent on microRNA-34c.
    -> Discovery of the presence of microRNA-34a in the testicular spermatogonial cells. MicroRNA-34a is absent in spermatozoa. Now it is well known that microRNA-34a is a critical regulator of sperm production in the male testis.
    -> Reduced presence of microRNA-34 family are involved in oxidative stress.
    -> Discovered that embryonic stem cells and cancer cells have similarities in microRNA-34 family expression. Now it is known that microRNA-34a is a critical regulator of cancer stem cells of almost each and every cancer type of humans.
    -> Presence of multiple initiation codons in the mRNA of SLC4A11 which is known be critically involved in different eye diseases at least. Now it known that different variants of SLC4A11 are produced inside the cells depending on the alternative translational initiation.
    Current research interests of Dr. Khokon Kumar Dutta include the roles of thioredoxin-binding protein-2, TBP-2 (also known as thioredoxin-interacting protein, TXNIP) and microRNA-34family in the pathophysiology of diabetes and diabetes related complications.

Current Research


  • Mitochondrial TXNIP (TBP-2) and the harmful consequences of diabetes.

Research Interests


  • To investigate the possibility of diabetes treatment by blocking the entry of TXNIP (TBP-2) protein inside the mitochondria.

Degree Name Group/Major Subject Board/Institute Country Passing Year
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Doctor of Philosophy (Ph.D); Pathology and Biology of Diseases; School of Medicine, Kyoto University; Japan, 2007.

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Masters of Science (M.Sc.) (Thesis Group); Biochemistry and Molecular Biology; Dhaka University; Bangladesh, 2000.

Bachelor of Science (Hons.); Biochemistry and Molecular Biology; Dhaka University; Bangladesh; 1998.

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Course Material


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Publication TypePublication TitlePublished Year
Mohammad Asaduzzaman, Md. Mahbub Ullah, Sayed Md. Redwan, Md. Jahangir Alam, Farha Matin Juliana, Nazmul Hossain, Biswajit Das, Runa Asma, Manoj Mandal and Khokon Kumar Dutta. Emergence of Meropenem Resistance in Pathogens Recovered From Urine Cultures in Bangladesh. Journal of Pharmacy and Biological Sciences. 2018 May-June; 13: 41-47. View2018
Mohammad Asaduzzaman, AsminiShobnam, Md. Farukuzzaman, Abdul Gaffar, Farha Matin Juliana, Tanima Sharker, Khokon Kumar Dutta, Mohammod Johirul Islam. Assessment of Red Blood Cell Indices, White Blood Cells, Platelet Indices and Procalcitonin of Chronic Kidney Disease Patients under Hemodialysis. International Journal of Health Sciences and Research. 2018 August; 8: 98-109. View2018
S. S. Jalimarada; K. K. Dutta; E. N. Vithana; J. A. Bonanno.Expression of the Borate Transporter NaBC1 (SLC4A11) in Bovine Corneal Endothelial Cells (BCEC). Investigative Opthalmology& Visual Sciences. 2009 April; 50: 1801. View2009
K. K. Dutta,S. J. Shivakumar, T. Nguyen,C. Liu, E. Vithana,J. A. Bonanno. Cloning and Characterization of the Borate Transporter SLC4A11in Bovine Corneal Endothelial Cells. Investigative Opthalmology& Visual Sciences. 2009 April; 50: 1797 View2009
JournalC. Liu, M. Calvin, K. Dutta, J. Bonanno. SOD2 Gene Expression and SiRNA Knockdown in Rabbit Corneal Endothelial Cells. Investigative Opthalmology & Visual Sciences. 2009 April; 50: 1825 View2009
Janice Onuki , Yu-Ting Liu, Wen-Hua Lee , Li Jiang, Khokon K Dutta, Yi Zhong, Shinya Akatsuka, Shinya Toyokuni. ANALYSIS OF TARGET GENES ON CHROMOSOME 8 IN Fe-NTA-INDUCED RAT RENAL CELL CARCINOMA. International Union of Biochemistry and Molecular Biology.2007 View2007
Shinya Toyokuni, K. K. Dutta. Shinya Akatsuka. Novel approach for elucidation of iron-induced carcinogenesis: Oxygenomics and micro-RNA. American Journal of Hematology. 2007 June; 82 (6): 512 View2007
Liu YT, Shang D, Akatsuka S, Ohara H, Dutta KK,Mizushima K, Naito Y, Yoshikawa T, Izumiya M, Abe K, Nakagama H, Noguchi N, Toyokuni S. Chronic oxidative stress causes amplification and overexpression of ptprz1 protein tyrosine phosphatase to activate beta-catenin pathway. American Journal of Pathology. 2007 Dec;171(6):1978-88. View2007
Dutta KK, Zhong Y, Liu YT, Yamada T, Akatsuka S, Hu Q, Yoshihara M, Ohara H, Takehashi M, Shinohara T, Masutani H, Onuki J, Toyokuni S. Association of microRNA-34a overexpression with proliferation is cell type-dependent. Cancer Science. 2007 Dec; 98(12):1845-52.  View2007
Involvement of aminoacylase 1 in ferric nitrilotriacetate (Fe-NTA)-induced rat renal cell carcinoma2006
Distribution of oxidative DNA lesions across the entire genome. International Congress of Biochemistry and Molecular Biology and FAOBMB Congress. 2006 View2006
Lee WH, Akatsuka S, Shirase T, Dutta KK, Jiang L, Liu YT, Onuki J, Yamada Y, Okawa K, Wada Y, Watanabe A, Kohro T, Noguchi N, Toyokuni S. Alpha-tocopherol induces calnexin in renal tubular cells: another protective mechanism against free radical-induced cellular damage. Arch BiochemBiophys. 2006 Sep 15;453(2):168-78.  View2006
Akatsuka S, Aung TT, Dutta KK, Jiang L, Lee WH, Liu YT, Onuki J, Shirase T, Yamasaki K, Ochi H, Naito Y, Yoshikawa T, Kasai H, Tominaga Y, Sakumi K, Nakabeppu Y, Kawai Y, Uchida K, Yamasaki A, Tsuruyama T, Yamada Y, Toyokuni S. Contrasting genome-wide distribution of 8-hydroxyguanine and acrolein-modified adenine during oxidative stress-induced renal carcinogenesis. American Journal of Pathology. 2006 Oct;169(4):1328-42.  View2006
Li Jiang 1, Yi Zhong, Shinya Akatsuka, Yu-Ting Liu, Khokon Kumar Dutta, Wen-Hua Lee, Janice Onuki, Ken-ichiMasumura, Takehiko Nohmi, Shinya Toyokuni. Deletion and single nucleotide substitution at G:C in the kidney of gpt delta transgenic mice after ferric nitrilotriacetate treatment. Cancer Science. 2006 Nov; 97(11):1159-67 View2006
Shinya Toyokuni, Shinya Akatsuka, T T Aung, K K Dutta. Free radical-induced carcinogenesis: Target genes and fragile genome sites. Free Radical Research. 2005 View2005
Characteristics of Oxidative Damage Localization in the Genome DNA. HUGO. 2005.2005
Dutta KK, Nishinaka Y, Masutani H, Akatsuka S, Aung TT, Shirase T, Lee WH, Yamada Y, Hiai H, Yodoi J, Toyokuni S. Two distinct mechanisms for loss of thioredoxin-binding protein-2 in oxidative stress-induced renal carcinogenesis. Lab Invest. 2005 Jun;85(6):798-807.  View2005
Shinya Toyokuni andK K Dutta. Rattus norvegicus vdup1 gene, 5'UTR, strain: Brown-Norway. Genbank. 2004 August. View2004
Toyokuni S and Dutta K K. Rattus norvegicus vdup1 gene, 5'UTR, strain: Wistar/Fischer-344. Genbank. 2004 August.2004
Qadri F, Bhuiyan TR, Dutta KK, Raqib R, Alam MS, Alam NH, Svennerholm AM, Mathan MM. Acute dehydrating disease caused by Vibrio cholerae serogroups O1 and O139 induce increases in innate cells and inflammatory mediators at the mucosal surface of the gut. Gut. 2004 Jan;53(1):62-9.  View2004
journal ArticleFirdausi Qadri, Tanvir Ahmed, Firoz Ahmed, R. Bradley Sack, David A. Sack, Ann Mari Svennerholm, Yasmin Ara Begum, Nargis Akter, Khuzista Akhter, Perveen Begum, Razia Begum, Taufiqur Rahman, Khokon Kumar Dutta, Delowar Hossain, Prodip Chandra Das, Lutfur Rahman. Safety and immunogenicity of an oral, inactivated enterotoxigenic Escherichia coli plus cholera toxin B subunit vaccine in Bangladeshi children 18-36 months of age. Vaccine. 2003 June; 21: 2394-2403. View2003
Journal Papers Not Available
Conference Papers Not Available

Book/Book Chapter

Book Name Author Name Publish Organization Publish Year
Book not Found!